调查营养与阿尔茨海默病之间的潜在关联
Mingyue He1, Tenghong Lian2, Zhan Liu1
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Frontiers in nutrition
|March 22, 2024
概括
营养不良在阿尔茨海默病 (AD) 中很常见. 较低的BMI,蛋白质和白蛋白水平与AD有关,白蛋白和MNA得分有助于区分阶段. 早期的营养干预可以使AD患者受益.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 营养科学 营养科学
背景情况:
- 营养不良是阿尔茨海默病 (AD) 患者中普遍存在的问题.
- 缺乏对阿尔茨海默病患者的全面营养状况评估.
- 这项研究研究了营养指数与阿尔茨海默病在不同阶段之间的关联.
研究的目的:
- 评估营养状况与阿尔茨海默病之间的关系.
- 确定与AD不同阶段相关的关键营养指标.
- 评估营养干预措施在治疗AD方面的潜力.
主要方法:
- 涉及正常认知 (NC) 和AD患者 (轻度认知障碍[AD-MCI]和痴呆症[AD-D]) 的横截面研究.
- 收集了有关人口统计,身体组成,饮食模式,营养评估尺度 (迷你营养评估[MNA],老年营养风险指数[GNRI]) 和实验室变量的数据.
- 利用二进制后勤回归和接收器运行特征 (ROC) 曲线来分析关联.
主要成果:
- 较低的BMI,小腿周长,MNA,GNRI,总蛋白,专蛋白,全球蛋白和阿波利波蛋白A1与AD相关 (p <0.05).
- 总蛋白质和白蛋白最好地区分AD与非AD (AUC0.80),通过添加小牛周长和MNA得分 (AUC0.83) 来改善.
- 专蛋白区分NC和AD-MCI (AUC0.75),而MNA得分区分AD-MCI和AD-D (AUC0.72). 专蛋白区分NC和AD-MCI (AUC0.75),而MNA得分区分AD-MCI和AD-D (AUC0.72). 专蛋白区分NC和AD-MCI,而MNA得分区分AD-MCI和AD-D (AUC0.72). 专蛋白区分NC和AD-MCI,而MNA得分区分AD-MCI和AD-D.
结论:
- 与对照人群相比,阿尔茨海默病患者的营养状况明显受到损害.
- 营养状况随着AD的进展而恶化.
- 早期识别和干预营养风险或营养不良可能会降低AD风险和进展.
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