晚期HNSCC对免疫检查点抑制的治疗反应与激活的效应者记忆T细胞表型相关
Max Schumacher1, Sina Beer1, Emmanuelle Moraes Ribeiro1
1Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany.
Frontiers in oncology
|March 22, 2024
概括
周围血液免疫细胞的变化可以预测头癌对PD-1抑制剂的反应. 识别这些免疫特征可能有助于选择免疫治疗的患者,并改善治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 局部晚期或转移性头支状细胞癌 (HNSCC) 的预后不佳.
- PD-1 抑制剂可以提高HNSCC的生存率,但只能使一小部分患者受益.
- 缺乏可靠的生物标志物来预测和监测HNSCC中的免疫治疗反应.
研究的目的:
- 在接受PD-1抑制的HNSCC患者中表征外周血液淋巴细胞子集.
- 为了识别与治疗反应与失败相关的免疫特征.
- 探索潜在的生物标志物,以早期识别耐火患者.
主要方法:
- 对外围血液淋巴细胞子集的分析,包括CD3+效应记忆 (CD3/EM) 细胞,CD69和CTLA-4表达.
- 在基线和PD-1抑制治疗期间,响应和不响应的HNSCC患者之间的免疫特征的比较.
- 在3个月和治疗失败时评估免疫细胞群.
主要成果:
- 响应的患者在3个月后显示CD3+效应记忆 (CD3/EM) 细胞增加和T细胞上CD69表达升高.
- 没有反应的患者在治疗失败时表现出较低的绝对淋巴细胞数量和CD4+和CD8+效应体记忆T细胞上CTLA-4表达的增加.
- 显著的外周血液免疫特征与对HNSCC中PD-1抑制的反应或失败相关.
结论:
- 周围血液免疫特征可以作为生物标志物,用于预测HNSCC对PD-1抑制剂的反应.
- 早期识别不响应者可能有助于及时采取替代治疗策略.
- 向T细胞表型或结合免疫检查点抑制剂可以提高HNSCC的治疗疗效.
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