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Updated: Jun 21, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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响应微环境的金属网络释放平台,具有ROS清理,抗热和ECM再生,用于椎间盘退化

Hao Zhou1,2, Jinpeng He1, Renfeng Liu1

  • 1Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.

Bioactive materials
|March 22, 2024
PubMed
概括

一个新的金属网络平台,TMP@Alg-PBA/PVA,通过减少氧化应激和炎症,有效治疗椎间盘退化 (IVDD). 这种创新方法显示出在IVDD治疗中临床应用的巨大潜力.

关键词:
通过IL-17/ERK信号通路传递信号.椎间盘退化 椎间盘退化金属 - 网络金属 - 网络热灭菌的发生.有反应性氧物种的反应性氧物种.

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Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
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Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...