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来自免疫检查点抑制剂的免疫相关不良事件的知识领域和新兴趋势:一个参考资料和可视化分析

Jun Zhao¹, Yujie Feng², Guang-Wei Liu³

¹Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.

|March 22, 2024

概括

免疫检查点抑制剂 (ICI) 的免疫相关不良事件 (irAEs) 的研究正在增长. 未来的趋势包括专注于病例报告和了解黑色素瘤和肺癌中的irAEs.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
与免疫相关的不良事件 (irAEs) 是与ICI治疗相关的重大临床挑战.
了解irAEs的研究环境对于推进患者护理至关重要.

研究的目的:

调查免疫检查点抑制剂 (ICI) 诱导的免疫相关不良事件 (irAEs) 的研究热点和未来趋势.
为ICI诱导的IRE领域的研究人员提供有价值的见解.

主要方法:

从Web of Science核心集合数据库中对514篇英语文章进行了文献计量分析.
使用定量统计和可视化软件分析出版趋势,国家,机构,关键词和引用的文件.
确定了包括疾病,药物和特定不良事件在内的关键研究领域.

主要成果:

美国,日本和中国是ICI相关IRAE研究的领先国家.
德克萨斯大学MD安德森癌症中心,达纳-法伯癌症研究所和马萨诸塞总医院是顶级研究机构.
研究热点包括黑色素瘤,肺癌,肝细胞癌,乳腺癌和特定的irAEs,如白风和甲状腺功能障碍. 与irAEs相关的关键词显示频率越来越高.

结论:

由ICI引起的IRE的领域是充满活力和不断扩大的.
未来的研究可能将重点放在病例报告和特定不良事件上,如白风,甲状腺功能障碍,胰腺炎,胆管炎和风湿.
继续对irAEs管理和生物标志物的研究对于优化癌症免疫治疗至关重要.

关键词:

图书统计学图书统计学免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件.进行可视化分析分析.

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