通过氧化蛋白修饰,在先天免疫中发出ROS信号
Renuka Ramalingam Manoharan1, Ankush Prasad1, Pavel Pospíšil1
1Department of Biophysics, Faculty of Science, Palacký University, Olomouc, Czechia.
Frontiers in immunology
|March 22, 2024
概括
活性氧物种 (ROS) 和活性物种 (RNS) 对于天生的免疫力至关重要,调节免疫细胞功能和病原体防御. 本综述探讨了它们在免疫细胞激活和蛋白质修饰中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 天生的免疫力是对病原体的主要防御.
- 活性氧物种 (ROS) 和活性物种 (RNS) 是先天免疫反应的关键媒介.
- 这些反应性物种对于细胞信号传递,增殖和免疫细胞功能至关重要.
研究的目的:
- 审查参与免疫反应激活的氧化还原因子.
- 阐明ROS在免疫细胞内的氧化蛋白修饰中的作用.
- 检查ROS参与巨细胞极化和中性粒细胞功能.
主要方法:
- 文献综述侧重于先天免疫,ROS,RNS和氧化还原信号传递.
- 涉及NADPH氧化酶,髓氧化酶 (MPO) 和反应性物种生产的生物化学途径的分析.
- 检查ROS对氧化回应转录因子 (NF-kB,NRF2,HIF-1) 和表观遗传修饰的影响.
主要成果:
- ROS和RNS通过诸如呼吸突发和炎症酶激活等机制产生.
- 由NADPH氧化酶产生的过氧化 (H2O2) 被MPO利用来产生用于杀死病原体的低酸 (HOCl).
- 通过调节氧还原敏感转录因子和表观遗传修饰,ROS调节免疫细胞的生存和功能.
结论:
- 氧化还原平衡对于免疫细胞的生存和功能至关重要.
- ROS在巨细胞两极分化和中性粒细胞效应因子功能中起着重要作用.
- 了解ROS信号对于理解先天性免疫反应和开发治疗策略至关重要.
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