尾肌纤维瘤的流行病学和生存因素:一项SEER回顾性研究
Victoria Dahl1, Yonghoon Lee1, William Rate2
1Miller School of Medicine, University of Miami, Miami, United States.
概括
与其他软组织肉瘤 (STS) 相比,肌纤维肉瘤 (MFS) 患者的生存率较低,在诊断时年龄较大. 多次硬症的发病率和生存率正在上升,突出显示需要更好的监测和治疗策略.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 手术病理学手术病理学
背景情况:
- 肌纤维肉瘤 (MFS) 是一种罕见的软组织肉瘤 (STS),人口统计和预后因素不明.
- 发病率有限阻碍了对MFS特征和结果的强大研究.
- 将MFS与所有STS更广泛的类别进行比较对于理解其独特方面至关重要.
研究的目的:
- 描述一个患有MFS的大型患者队列.
- 评估MFS的流行病学因素.
- 将MFS的生存因子与所有STS进行比较.
主要方法:
- 对监测,流行病学和最终结果 (SEER) 数据库 (2000-2015) 的回顾性审查.
- 确定了1,440个MFS和12,324个STS病例.
- 卡普兰-梅尔生存分析和危险比率 (HRs) 的考克斯回归.
主要成果:
- 对于MFS (67%) 和STS (79%) 的总生存率较低.
- 在诊断时,MFS患者年龄较大 (62岁相比56岁),年龄较大是一个显著的负预后因素 (HR=7.94).
- 每年,MFS的发病率比STS (1.25%) 的增长率高 (2.59%);对于2008年后的两种情况,生存率都有所改善.
结论:
- 在人口统计和生存率方面,MFS与其他STS之间存在显著的差异.
- 与一般的STS相比,MFS显示出明显的流行病学和生存概况.
- 持续监测MFS等罕见瘤的发展趋势对于改善诊断和治疗至关重要.
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