甲胺和胰腺神经内分泌瘤:一个系统的审查和元分析
Maja Cigrovski Berkovic1, Alessandro Coppola2, Vibor Sesa3
1Department for Sport and Exercise Medicine, Faculty of Kinesiology University of Zagreb, Zagreb 10000, Croatia. maja.cigrovskiberkovic@gmail.com.
World journal of gastroenterology
|March 22, 2024
概括
2型糖尿病 (T2DM) 是胰腺神经内分泌瘤 (pNETs) 的风险因素,预测结果较差. 甲胺是一种甲胺.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 胰腺神经内分泌瘤 (pNETs) 往往进展,需要新的,耐受良好的疗法.
- 甲福明是一种2型糖尿病 (T2DM) 药物,通过抑制mTOR酸化,显示出在癌症治疗中的潜力.
- 本综述评估了T2DM和甲胺对pNET发育和患者结局的影响.
研究的目的:
- 系统地审查关于T2DM和甲福林在pNET起义中的作用的证据.
- 评估T2DM和甲福林对pNET结果的诊断和预后价值.
- 分析对无瘤存活率 (TFS),整体存活率和无进展存活率的影响.
主要方法:
- 发表文献的系统审查.
- 专注于研究T2DM和甲胺在pNET爆发和预后中的研究.
- 对结果的分析,包括无瘤存活率,整体存活率和无进展存活率.
主要成果:
- 根据5项研究 (809名患者) 的数据,T2DM与pNET出现相关 (OR = 2.13,P < 0.001).
- 在pNET患者中,T2DM与治疗后无瘤存活率 (TFS) 较差有关 (HR = 1.84,P < 0.001).
- 对甲福明的有限研究产生了异质的结果,缺乏诊断或预后的统计学意义.
结论:
- T2DM是pNET暴发的风险因素,也是治疗后TFS不良的预测因素.
- 关于甲福明的异质数据不足,限制了关于其在pNET诊断和预后中的作用的结论.
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