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最近与年龄相关的代谢功能障碍相关的脂肪性肝病的进展

Qian-Jun He¹, Yi-Fei Li², Ling-Tong Zhao¹

¹College of Basic Medicine, Beihua University, Jilin 132013, Jilin Province, China.

World journal of gastroenterology

|March 22, 2024

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 与衰老有关,构成日益严重的全球健康挑战. 针对衰老机制为MASLD治疗提供了一个新的治疗策略.

科学领域:

肝病学肝病学是一种肝病学.
老年学是一门学科.
代谢疾病代谢疾病

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球25%的人口,成为慢性肝病的主要原因.
人们越来越认识到MASLD与衰老过程有关.
人口老龄化意味着与年龄相关的MASLD将升级为全球重要的健康问题.

研究的目的:

审查有关老化相关因素和MASLD潜在治疗点的当前研究.
探索氧化应激,自,线粒体平衡,胆酸代谢和与年龄相关的MASLD中的失生症的作用.
确定有效的治疗策略来管理与年龄相关的MASLD及其进展.

主要方法:

关于研究衰老和MASLD的研究的文献综述.
对与衰老相关的关键因素的研究分析:氧化应激,自,线粒体平衡,胆酸代谢和失生症.
综合发现,以确定治疗点.

主要成果:

衰老是MASLD发展和进展的一个重要因素.
一些生物途径,包括氧化应激,受损的自,线粒体功能障碍,改变胆酸代谢和肠道功能障碍,都与年龄相关的MASLD有关.
这些途径代表了治疗干预的潜在目标.

结论:

针对衰老过程的干预措施对治疗MASLD充满希望.
解决氧化应激,自,线粒体功能,胆酸平衡和肠道微生物群可能会减轻与年龄相关的MASLD.
对这些目标的进一步研究可能会导致对这种日益严重的健康问题进行有效的治疗.

关键词:

衰老的衰老衰老的衰老胆酸的平衡是胆酸的平衡.失生症是一种失生症.与代谢功能障碍相关的脂肪性肝病.线粒体的恒常性平衡.

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