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在县医院环境下对多微生物和抗生素耐药性传染性角质炎的表征

Lawrence Chan¹, Jacqueline B Lopez¹, Murtaza Saifee¹

¹University of California, San Francisco, Department of Ophthalmology, San Francisco, CA, USA.

Cornea open

|March 22, 2024

概括

无家可归增加了多微生物角质炎和多药物耐药性的风险. 建议对这一群体进行早期的广泛抗生素覆盖,因为之前的局部抗生素没有提高感染风险,结果也没有显著恶化.

科学领域:

眼科医生眼科眼科
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

传染性角膜炎是视力丧失的重要原因,不成比例地影响低收入人群.
了解感染性角膜炎中健康的社会决定因素的作用对于有针对性的干预至关重要.

研究的目的:

研究社会风险因素与多微生物角膜炎,多药性耐药性,病原体谱和临床结果之间的关联.
分析无家可归和先前使用抗生素对传染性角质炎特征和治疗反应的影响.

主要方法:

在县医院 (2010-2021) 的174名感染性角膜炎患者的回顾性研究.
多变量回归分析以评估社会,医学和精神病学因素与多微生物生长和多药物耐药性之间的关系.
评估临床结果,包括的尺寸,视力敏度和紧急手术的需要.

主要成果:

无家可归患者患多微生物角质炎的可能性更高 (OR3.4,p=0.023).
多微生物感染与多抗药性生物体 (p=0.018) 相关,并增加了强化抗生素的需求 (OR 2.9,p=0.011).
之前的局部抗生素使用与多微生物或多药物耐药性感染的风险增加无关.

结论:

无家可归是多微生物角质炎和随后的多药性耐药性的重要危险因素.
这些发现支持为患有角膜炎的无家可归患者启动广泛的抗生素覆盖.
多微生物角膜炎并没有显著影响临床结果,例如视力敏度或解决时间.

关键词:

抗生素耐药性抗生素耐药性县医院县医院县医院传染性角质炎是一种传染性角质炎.它们是多微生物的.

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