烟草使用和急性中风风险在32个国家的INTERSTROKE研究:一个病例对照研究
Xingyu Wang1,2, Xin Liu1,2, Martin J O'Donnell3,4
1Beijing Hypertension League Institute, Beijing, China.
EClinicalMedicine
|March 22, 2024
概括
当前吸烟显著增加了中风风险,特别是缺血性中风. 环境烟草烟雾 (ETS) 也会以剂量依赖的方式增加中风风险,这凸显了全球烟草控制战略的必要性.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 心血管疾病研究研究
背景情况:
- 吸烟是导致中风的全球主要危险因素.
- 以前的研究表明,目前的吸烟导致全球人口中风的可归因风险 (PAR) 为12.4%.
研究的目的:
- 调查各种烟草暴露 (当前使用,环境烟草烟雾) 与中风风险之间的关联.
- 根据中风亚型,地理区域和国家收入水平分析中风风险.
主要方法:
- 国际中风研究 (INTERSTROKE) 是一项全球病例控制研究,包括13,462例中风病例和13,488例对照病例.
- 分析了烟草使用,环境烟草烟雾 (ETS) 暴露和中风 (整体,缺血性,脑内出血) 和病因亚型之间的关联.
主要成果:
- 当前吸烟增加了整体中风风险 (OR 1.64) 和缺血性中风风险 (OR 1.85) 超过了脑内出血 (OR 1.19).
- 风险和PAR因地区和收入而异,高收入国家呈现最高赔率 (OR3.02) 和PAR (18.6%).
- 暴露在ETS中显示了中风风险的剂量依赖性增加,每周>10小时与所有类型的中风风险更高的几率相关.
结论:
- 与烟草类型,活跃使用,ETS暴露和国家收入相关的中风风险幅度和PAR存在显著的全球变化.
- 实施有针对性的战略以阻止一切形式的烟草使用和促进无烟环境对于减少全球中风负担至关重要.
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