在住院COVID-19患者的长期功能能力和生活质量下降
Anderson Donelli da Silveira1,2, Fernando Luis Scolari1,2,3,4, Marina Petersen Saadi1,2
1Division of Cardiology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
长期COVID幸存者在出院7个月后表现出减少的运动能力和生活质量. 这些发现凸显了COVID-19对身体功能和福祉的持续影响.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 在COVID-19后报告了持续的症状和运动不耐受性.
- 对运动能力和与健康相关的生活质量 (HRQoL) 的长期影响尚不清楚.
研究的目的:
- 评估住院COVID-19患者的长期功能能力和HRQoL.
主要方法:
- 前性队列研究与倾向性得分匹配的对照 (1: 3比率).
- 包括退院后的COVID-19患者,在CT扫描上有肺部干扰.
- 心肺运动测试 (CPET) 和SF-36 HRQoL问卷在COVID-19后6个月进行.
主要成果:
- 与对照组 (n=141) 相比,COVID-19患者 (n=47) 的预测峰值氧气消耗 (ppVO2) 的百分比较低 (83%与95%,p=0.002).
- 在COVID-19幸存者中观察到降低的平均VO2峰值和氧气吸收效率斜率 (OUES).
- 51%的COVID-19患者出现呼吸功能障碍;HRQoL显著降低,与峰值运动能力相关.
结论:
- 住院的COVID-19患者在出院后7个月内表现出功能能力降低和HRQoL.
- 降低HRQoL与该人群中VO2峰值降低相关.
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