相关实验视频

Updated: Jul 12, 2026

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

在小鼠中类似调整扭曲产物耳声发射比率函数和耳震动

James B Dewey¹, Christopher A Shera^1,2

¹Caruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA 90033, USA.

AIP conference proceedings

|March 22, 2024

概括

扭曲产物音声发射 (DPOAE) 调与小鼠的耳机械调非常相似. 这表明DPOAEs可能会非侵入性地评估耳频率调.

科学领域:

听觉神经科学听觉神经科学
耳声波排放耳声波排放耳声波排放
耳机械学耳机械学

背景情况:

扭曲产物音声发射 (DPOAEs) 显示当刺激音调的频率比变化时带宽幅度形状.
假设这种DPOAE调与耳频率调有关,但缺乏将DPOAE与耳机械反应联系起来的直接证据.

研究的目的:

直接比较DPOAE和小鼠耳机械振动的调特性.
调查负责DPOAE振幅与频率比函数中带径形状的潜在机制.

主要方法:

在CBA/CaJ小鼠中测量DPOAEs,使用固定-f2,扫描-f1范式.
用光学连贯断层扫描测量了基底膜和构造膜的耳振动,这些振动在f2附近的特征频率的位置进行了测量.
系统地改变了刺激水平,以评估调的清晰度.

主要成果:

DPOAE振幅与f2/f1比率函数的调敏度与基底和/或构造膜振动的调敏度非常相匹配.
随着刺激水平的下降,DPOAEs和耳振动的调敏度同样增加.
这种关系在一系列f2频率 (大约8-22kHz) 中是一致的.
单独的耳内干扰产品并没有产生带通形状,这表明波干扰有助于DPOAE调.

结论:

DPOAE调特性,特别是振幅与频率比的带通形状,与小鼠的耳机械调有很强的相关性.
这些发现支持DPOAEs作为推断耳频调的非侵入性工具的潜在使用.
需要进一步的研究来证实这些关系在其他物种和跨不同的频率范围.

更多相关视频

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

相关概念视频

The Cochlea

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.

Echo

Echo

The human ear cannot distinguish between two sources of sound if they happen to reach within a specific time interval, typically 0.1 seconds apart. More than this, and they are perceived as separate sources.
Imagine the sound is reflected back to the ears. Assuming that the source is very close to the human, the difference between hearing the two sounds—the emitted sound and the reflected sound—may be more than the minimum time for perceiving distinct sounds. If this is the case, then the...