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Updated: Jun 30, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

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抗体与药物合物的药物化学演变

Adrian D Hobson1

  • 1AbbVie Bioresearch Center, 381 Plantation Street, Worcester Massachusetts 01605 USA adrian.hobson@abbvie.com.

RSC medicinal chemistry
|March 22, 2024
PubMed
概括

药物化学优化了抗体-药物联合体 (ADCs) 通过提炼抗体,链接器和有效载荷. 这些组件的战略设计增强了ADC的稳定性,功效和选择性,以改善治疗结果.

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