婴儿的表现和结果 ≤90天 带有和没有SARS-CoV-2
Brett Burstein1, Vikram Sabhaney2, Todd A Florin3
1Montreal Children's Hospital, Division of Pediatric Emergency Medicine, McGill University Health Centre, and Department of Biostatistics, Epidemiology, and Occupational Health, McGill University, Montreal, Quebec, Canada.
Pediatrics
|March 22, 2024
概括
在90天以下的婴儿中,严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染通常比类似疾病温和. 对SARS-CoV-2的测试有助于在幼儿中进行临床管理.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 90天以下的婴儿出现严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 症状需要仔细评估.
- 区分SARS-CoV-2和其他常见的婴儿疾病可能是具有挑战性的,因为重叠的症状.
研究的目的:
- 为了比较90天或更年轻的婴儿的临床症状和结果,这些婴儿被测试了SARS-CoV-2.
- 分析来自大量国际婴儿队伍的数据,这些婴儿与疑似SARS-CoV-2一起到急诊室.
主要方法:
- 对0-90天龄的婴儿怀疑感染SARS-CoV-2的数据进行了二次分析,并通过分子检测证实了这一点.
- 从10个国家的41个急救部门和加拿大的14个急救部门收集了数据,随访时间为14天.
- 评估的临床结果包括住院治疗,重症监护室 (ICU) 住院治疗,以及严重的结果 (综合性强度干预,器官损伤或死亡).
主要成果:
- 在1048名接受测试的婴儿中,96.1%的婴儿有症状,41.2%的婴儿检测出SARS-CoV-2阳性.
- 无呼吸和昏昏欲睡等全身症状在所有婴儿中都是常见的,不论SARS-CoV-2的状态如何.
- 与SARS-CoV-2阴性婴儿相比,患有SARS-CoV-2的婴儿不太可能住院,需要ICU入院或经历严重后果.
结论:
- 虽然最小婴儿的SARS-CoV-2感染可以模仿其他疾病,但它们往往呈现出较轻微的临床过程.
- 对SARS-CoV-2的诊断测试对于指导呼吸系统症状的婴儿临床管理决策是有价值的.
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