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Updated: Jun 30, 2025

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
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微弱酸性pH响应的脂质体含量释放,由丁修饰剂诱导

Ayumi Kashiwada1,2, Narumi Taoka1, Yukiha Chijimi1

  • 1Department of Applied Molecular Chemistry, College of Industrial Technology, Nihon University, 1-2-1, Izumi-cho, Narashino, Chiba, 275-8575, Japan. kashiwada.ayumi@nihon-u.ac.jp.

Organic & biomolecular chemistry
|March 22, 2024
PubMed
概括

由胺修饰的脂质体提供受控的药物释放,由内部pH值变化引发. C12-他的脂质体表现出显著的pH依赖释放,为向治疗输送系统铺平了道路.

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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