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咖啡因对3DRISM研究中的粉样蛋白-β-A聚合物的影响

Priya Dey1, Parbati Biswas1

  • 1Department of Chemistry, University of Delhi, Delhi 110007, India.

The Journal of chemical physics
|March 22, 2024
PubMed
概括

咖啡因可以通过防止粉样β聚合来抑制阿尔茨海默病的进展. 这项研究使用了分子动力学模拟来显示咖啡因改变了粉样β二元体的免水化能量,这表明阿尔茨海默病治疗的治疗潜力.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...