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相关概念视频

MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...

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相关实验视频

Updated: Jun 21, 2026

Extraction and Analysis of Cortisol from Human and Monkey Hair
08:38

Extraction and Analysis of Cortisol from Human and Monkey Hair

Published on: January 24, 2014

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单个头发分析用于马-酸-方法优化,验证和应用.

Christopher Wiedfeld1, Gisela Skopp1, Frank Musshoff1

  • 1Forensic Toxicological Center (FTC) Munich, Munich, Germany.

Drug testing and analysis
|March 22, 2024
PubMed
概括

头发分析马酸 (GHB) 的检测窗口比体液的检测窗口更长. 分段单头发分析可以识别GHB摄入模式,尽管需要进一步验证.

科学领域:

  • 法医毒理学 法医毒理学
  • 分析化学 分析化学
  • 药理动力学 药理动力学

背景情况:

  • -酸 (GHB) 快速代谢,使体液中检测具有挑战性.
  • 头发分析为GHB提供了潜在的延长检测窗口.
  • 内源性GHB水平有所不同,这使得外源性摄入的鉴定变得复杂.

研究的目的:

  • 优化和验证一种GHB提取和量化在2毫米头发段中的方法.
  • 调查单头发微分析对于检测GHB摄入的有用性.
  • 为了建立GHB在头发中的时间度概况.

主要方法:

  • 优化和验证GHB提取和量化在2毫米的头发段.
  • 使用微分析分析五根单一的人类头发的分析.
  • 在非使用者和疑似使用者中比较GHB度.

主要成果:

  • 建立了一种经过验证的方法,其检测极限为2.5 pg/sec,定量下限为5 pg/sec.
  • 在非使用者中,GHB被检测到微量或根本没有.
  • 在一个据称的用户中,细分的头发形状中的可重复的最大度表明了GHB的摄入.
关键词:
黄金黄金 (GHB) 是一种可怕的药物.在 LCMS/MS 中使用.法医毒理学 法医毒理学微细分的微细分是指微细分.单个头发的分析.

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The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
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Gas Chromatography-Mass Spectrometry Paired with Total Vaporization Solid-Phase Microextraction as a Forensic Tool
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结论:

  • 分段单头发分析可以提供关于GHB摄入的时间信息.
  • 开发的方法对检测GHB摄入有希望,但结果需要进一步验证.
  • 这项研究介绍了对细分单一毛发的GHB测试的第一个发现.