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Updated: Jun 30, 2025

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
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过多的脂肪酸激活PRMT5/MDM2/Drosha通路,以调节miRNA生物发生和脂质代谢

Aijun Hou1,2, Xiaoding Xu1,3, Yu Zhang1,2

  • 1Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Liver international : official journal of the International Association for the Study of the Liver
|March 22, 2024
PubMed
概括

在非酒精性脂肪性肝病 (NAFLD) 中,过量的脂肪酸会破坏微RNA (miRNA) 生物发生. 棕酸激活了PRMT5-MDM2-Drosha信号,损害了miRNA的产生,并加剧了NAFLD的进展.

关键词:
德罗沙降解的降解方式这是NAFLD.在PRMT5中,脂质新陈代谢 脂质新陈代谢这就是miRNA生物生成的原因.

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