在COVID-19大流行期间病例数激增的措施和影响:系统性审查
Maniraj Neupane1,2, Nathaniel De Jonge1, Sahil Angelo3
1Clinical Epidemiology Section, Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD.
医院的流行病激增显著增加了患者的死亡率. 一项系统性审查发现,82%的研究报告称,激增期间死亡风险更高,突出了对标准化激增指标的需求.
科学领域:
- 公共卫生和流行病学
- 医疗保健管理的管理
- 关键护理医学 关键护理医学
背景情况:
- 由于COVID-19的流行,全球医院系统面临前所未有的压力.
- 了解患者病例数量激增对死亡率的影响,对于在公共卫生危机期间有效管理医疗保健至关重要.
研究的目的:
- 系统地审查和分析流行病病例数量激增的措施.
- 检查流行病激增指标与住院患者的死亡率之间的关联.
主要方法:
- 进行了2019年12月至2023年11月期间发表的研究的系统审查,这些研究在PubMed,Embase和Web of Science中进行了索引.
- 包括39项英语研究,报告了流行病激增措施和患者死亡率.
- 定性评估的激增措施和半定量聚合的因异质性而导致的激增死亡率关联.
主要成果:
- 包括39项研究,其中17项专注于重症监护室 (ICU) 设置.
- 确定了各种各样的37个激增指标,分为四个主题.
- 82%的研究 (32/39) 报告了案件数量激增和死亡率之间的有害关联,其中一些表明风险增加了多达四倍.
结论:
- 流行病病例数量的激增始终与不同环境和人群的生存率降低有关.
- 激增指标的显著异质性阻碍了直接比较和元分析,影响了概括性,特别是对中低收入国家 (LMICs).
- 迫切需要一种标准化,可扩展的激增指标,以准确地捕捉波动和未来的流行病期间的危害.
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