与多样化的城市人口中Onabotulinum Toxin-A停止相关的因素
Tyler Bergeron1, Arshia Aalami Harandi1, Mariel Liebeskind2
1From the Albert Einstein College of Medicine, Bronx, NY.
Urogynecology (Philadelphia, Pa.)
|March 22, 2024
概括
超过40%的患者因膀过活 (OAB) 暂停了纳博毒素-A (BTX-A) 治疗. 尿和更高的收入与停止治疗有关,而夜尿和急性尿失禁则预测继续治疗.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 过度活跃的膀 (OAB) 影响了16%的美国人,但先进的治疗方法仍未得到充分利用.
- 针对OAB的肠道上毒素-A (BTX-A) 注射具有很高的中止率 (25-51%),尽管需要重复治疗.
研究的目的:
- 为了确定与停止用于异常性过活性膀 (OAB) 的甲基毒素-A (BTX-A) 注射相关的因素.
- 分析患者的人口统计,病史,症状和BTX-A继续或停止治疗的结果.
主要方法:
- 对接受BTX-A治疗异形性OAB的成年患者的回顾性审查.
- 在停止和继续BTX-A治疗的患者之间,患者特征和术后结果的比较.
主要成果:
- 在246名患者中,40.7%的人停止了BTX-A. 停药与手术后尿 (18.4%与9.7%) 和更高的中位收入有关.
- 报告患有手术前夜尿 (57.2% vs 36.8%) 或急性尿失禁 (78.1% vs 64.6%) 的患者更有可能继续BTX-A治疗.
结论:
- 尿等不良事件与BTX-A停止相关.
- 预先存在的夜尿和UUI表明更严重的OAB,可能表明对BTX-A的反应和坚持更好.
- 高的戒断率需要进一步研究继续OAB治疗的障碍.
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