洞察男性不孕症的复杂性:一个多学科的综述
Rebeka Podgrajsek1, Alenka Hodzic2,3, Martin Stimpfel1,4
1Department of Human Reproduction, University Medical Center Ljubljana, Ljubljana, Slovenia.
Systems biology in reproductive medicine
|March 22, 2024
概括
异形男性不孕症研究受益于多omics方法. 整合基因组学,蛋白质组学和代谢学有助于确定新的生物标志物,以更好地理解和治疗男性生殖障碍.
科学领域:
- 生殖生物学 生殖生物学
- 遗传学 遗传学 是一个
- 生物化学 生物化学
背景情况:
- 男性不孕症影响40-50%的夫妇,在70%的病例中原因不明.
- 高通量技术和奥米克方法的进步为生物标志物发现提供了新的途径.
研究的目的:
- 审查关于男性不孕症的奥米克方法 (基因组学,表观基因组学,转录组学,ncRNAomics,蛋白质组学,代谢组学).
- 识别潜在的基因,转录,非编码RNA,蛋白质和代谢物,以便进一步研究.
- 为了比较基因本体学 (GO) 术语跨不同的奥米克数据集和评估重叠.
主要方法:
- 在PubMed (2014年2月 - 2022年6月) 上使用与男性不孕不育和omics相关的关键词进行系统的文献搜索.
- 检索研究的分析被分类为omics类型:基因组学,表观基因组学,转录组学,非编码RNA,蛋白质组学和代谢组学.
- 用Enrichr工具进行基因本体学 (GO) 丰富分析,以比较功能注释.
主要成果:
- 确定和分类了281项相关的全球研究.
- 基因组学是最受代表的奥米克方法 (171项研究),其次是蛋白质组学 (29) 和非编码RNA (31).
- 对GO术语的比较显示了不同omics方法之间的有限重叠,表明不同的分子因子识别.
结论:
- 不同的奥米克策略识别出男性不孕症中的不同分子因素.
- 整合多原子系统生物学方法对于发现生物标志物和了解男性不孕不育的全谱至关重要.
- 这种综合方法将促进男性不孕症的诊断,预后和治疗.
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