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在晚期早产和满期新生儿中使用抗生素
Johan Gyllensvärd1,2, Marie Studahl3,4, Lars Gustavsson3,4
1Department of Pediatrics, Ryhov County Hospital, Jönköping, Sweden.
JAMA network open
|March 22, 2024
概括
新生儿使用抗生素并没有增加早发性败血症 (EOS) 或死亡率. 需要继续努力,以减少新生儿不必要的抗生素处方.
科学领域:
- 新生儿护理 新生儿护理
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素治疗对于新生儿败血症至关重要,但过度使用可能导致抗生素耐药性和不良结果.
- 优化新生儿抗生素使用需要强大的监测数据.
研究的目的:
- 检查抗生素使用与早产败血症 (EOS) 发病率和死亡率在晚期早产和满期新生儿之间的关联.
- 为优化新生儿护理中的抗生素治疗策略提供数据.
主要方法:
- 在瑞典 (2012-2020年) 进行的一项全国性观察研究包括从34周怀孕开始的所有活产婴儿.
- 数据来源于瑞典新生儿质量登记册和瑞典医疗出生登记册.
- 分析的重点是抗生素暴露,培养证明的EOS和相关死亡率.
主要成果:
- 包括100多万名新生儿;1.88%在生命的第一个星期接受了抗生素.
- EOS的发病率显著下降,从每1000个活产儿的0.74降至0.34 (2012-2020年).
- 与EOS相关的死亡率为1.39%,并没有显著变化;抗生素使用与增加EOS风险或死亡率无关.
结论:
- 新生儿对抗生素的低暴露与EOS风险或死亡率的增加无关.
- 尽管抗生素使用稳定,但建议进一步减少新生儿不必要的抗生素处方.
- 这项研究强调了持续监测的必要性,以完善新生儿抗生素管理.
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