癌症查与多种癌症检测测试:一个翻译科学综述
Wendy S Rubinstein1, Christos Patriotis1, Anthony Dickherber2
1Division of Cancer Prevention, US National Cancer Institute, Rockville, Maryland, USA.
CA: a cancer journal for clinicians
|March 22, 2024
概括
多种癌症检测 (MCD) 测试对早期癌症查充满希望,识别各种癌症,包括那些没有当前方法的癌症. 然而,进一步的研究是必要的,以量化他们的好处和危害.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 生物标志物发现发现
背景情况:
- 多种癌症检测 (MCD) 测试使用单个生物标本为多种癌症提供并发查.
- 这些测试有可能改善早期检测,特别是对于缺乏当前查方法的癌症.
- 关于MCD测试的益处和危害存在重大不确定性.
研究的目的:
- 评估MCD测试在检测各种癌症方面的性能.
- 评估MCD测试对早期癌症诊断和患者结果的潜在影响.
- 确定有关MCD测试准确性和临床实用性的未来研究的关键领域.
主要方法:
- 分析了两项涉及超过16000人的前性研究.
- 对不同癌症类型和不同癌症阶段的MCD测试报告的敏感度的评估.
- 对癌症查遵守和诊断工作的潜在影响的审查.
主要成果:
- MCD测试发现了早期癌症,包括胰腺,卵巢,肝脏和血液恶性瘤,特别是那些没有标准查的癌症.
- 报告的敏感度在27%至95%之间,根据癌症类型而异,对于早期疾病通常较低.
- 负的MCD结果可能会导致虚假的安慰,可能会减少对标准查方案的遵守.
结论:
- MCD测试显示了早期检测各种癌症的潜力,但需要进一步验证.
- 预期的临床试验对于解决准确性,临床效用和人群特异性表现的不确定性至关重要.
- 澄清诊断途径和对阳性MCD测试的随访是安全和有效实施所必需的.
更多相关视频
10:34Identification of Sleeping Beauty Transposon Insertions in Solid Tumors using Linker-mediated PCR
Published on: February 1, 2013
14.1K
13:24Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
11.8K
相关概念视频
Mouse Models of Cancer Study
5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Cancer Vaccines
363
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
363
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Survival Analysis
345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
