心理药物使用与绝经后妇女身体功能之间的关系
Hind A Beydoun1,2, May A Beydoun3, Edward Kwon4
1Department of Research Programs, A.T. Augusta Military Medical Center, 9300 DeWitt Loop, Fort Belvoir, VA, 22060, USA. hind.baydoun@nih.gov.
GeroScience
|March 22, 2024
概括
心理药物使用,特别是抗抑郁药,与绝经后妇女的身体功能较差有关. 镇静剂/催眠药的使用也显示出复杂的关联,随着时间的推移,身体功能下降.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 妇女健康 妇女健康
背景情况:
- 身体功能随着年龄的增长而下降,特别是在更年期后.
- 精神药物通常被老年人使用,但它们对身体功能的影响尚未完全理解.
- 了解这些关系对于维持绝经后妇女的生活质量至关重要.
研究的目的:
- 研究心理药物使用 (抗抑郁药,抗焦虑药,镇静药/催眠药) 与绝经后妇女的身体功能之间的横截面和纵向关联.
- 区分各种类型的精神药物对自我报告和基于表现的身体功能的影响.
主要方法:
- 来自妇女健康倡议长寿研究 (WHI-LLS) 的4557名参与者的分析.
- 在入学和3年随访时评估的药物使用 (抗抑郁药,焦虑解消剂,镇静剂/催眠药).
- 使用短物理性能电池 (SPPB) 和RAND-36在约22年的多个时间点测量身体功能.
- 对相关共变量进行控制的多变量回归模型.
主要成果:
- 抗抑郁药的使用与自我报告的身体功能更差和基于表现的身体功能更差交叉相关.
- 在入学时使用抗抑郁药物预测了20年后更糟糕的基于表现的身体功能.
- 与非使用者相比,停止使用的镇静剂/催眠剂使用者表现出身体功能下降的速度更快.
- 抗焦虑药物与身体功能没有显著的关联.
结论:
- 抗抑郁药的使用与绝经后妇女的身体功能较差有关,无论是当前还是纵向.
- 镇静剂/催眠剂使用与身体功能下降之间的关系是复杂的,需要进一步研究.
- 这些发现强调了在绝经后妇女的医疗保健中考虑心理药物对身体功能的影响的重要性.
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