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相关概念视频

X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

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X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
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Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

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Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
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相关实验视频

Updated: Jun 30, 2025

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
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Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

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通过X射线光成像实现的代纳米粒子生物工程.

Giovanni M Saladino1, Bertha Brodin1, Ronak Kakadiya1

  • 1Department of Applied Physics, Biomedical and X-Ray Physics, KTH Royal Institute of Technology, SE 10691, Stockholm, Sweden.

Science advances
|March 22, 2024
PubMed
概括

这项研究引入了快速的全动物X射线光 (XRF) 成像,以快速评估纳米粒子 (NP) 分布,改善药物输送和成像. 该方法减少了器官积累,并在临床前研究中提高了瘤检测.

科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术 纳米技术
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 纳米粒子 (NP) 面临着药物输送和分子成像方面的挑战,原因是它们在肺和肝脏等器官的目标外积累.
  • 目前优化NP交付的方法涉及耗时的代工程和器官剖析.
  • 低准效率和信号噪声比阻碍了基于NP的治疗方法的临床转化.

研究的目的:

  • 开发一种快速,代的方法来评估纳米粒子分布在生物体内.
  • 为了提高纳米粒子准效率,并减少目标之外的积累.
  • 改进基于NP的治疗和诊断的临床前药理动力学研究.

主要方法:

  • 整个动物的X射线光成像 (XRF) 用于快速,系统地评估NP分布.
  • 基于的NP和克洛德罗纳酸脂质体被测试了瘤向与暂时的巨细胞枯竭.
  • 用X射线光计算断层扫描 (XFCT) 来进行瘤内3DNP分布分析.
  • 用染料合NP的多尺度成像和基因表达分析被用于验证和纳米毒理学分析.

主要成果:

  • 在XRF成像方法成功地减少了NP积累在肺和肝脏.
  • 暂时的巨细胞枯竭增强了瘤向和检测.

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相关实验视频

Last Updated: Jun 30, 2025

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Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

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Preparing Adherent Cells for X-ray Fluorescence Imaging by Chemical Fixation

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  • XFCT提供了瘤微环境内NP分布的详细3D可视化.
  • 经过验证的结果证实了开发的NP策略的有效性和安全性.

    • 结论:

    • 整体动物XRF成像提供了一种快速有效的方法来优化NP输送和评估生物分布.
    • 这种技术可以显著加快针对性NP治疗和诊断的发展.
    • 射频成像对推进临床前药理动力学研究和改善临床结果具有很大的潜力.