黑色素在持续性半脑和性半脑中存在
Sing-Ngai Cheung1,2, Renato Oliveira1,3, Peter J Goadsby1,4
1NIHR King's Clinical Research Facility & SLaM Biomedical Research Centre and Wolfson SPaRRC, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Cephalalgia : an international journal of headache
|March 22, 2024
概括
黑素为持续性半头 (HC) 和性半头 (PH) 提供了耐受性良好的治疗选择,在缓解症状方面表现出一些疗效. 虽然它不像印梅他辛那样有效,但它为对传统疗法不耐受的患者提供了可行的替代方案.
科学领域:
- 神经学 神经学
- 头痛 医学 医学 医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 持续性半头 (HC) 和性半头 (PH) 是三角形自主性脑痛.
- 印米他是黄金标准的治疗方法,但往往会导致不耐受.
- 梅拉托尼在结构上与印米他辛相似,正在作为一种替代疗法进行探索.
研究的目的:
- 评估黑激素在管理HC和PH的临床使用和疗效.
- 评估黑激素作为预防性头痛治疗的安全性和耐受性.
主要方法:
- 从国王学院医院 (2014-2023) 的患者记录的回顾性审计.
- 包括被诊断为HC或PH的患者,接受黑素治疗.
- 描述性统计数据用于分析患者人口统计,黑激素剂量和治疗结果.
主要成果:
- 在56名HC患者中,41%接受了黑激素,其中83%因副作用而停止了印米他辛. 61%的患者报告说,黑色素可以缓解头痛 (平均剂量为10毫克).
- 在22名PH患者中,27%接受了黑激素,50%报告了症状反应 (中位剂量为8mg).
- 黑色素一般被很好地容忍,罕见的副作用.
结论:
- 黑色素在治疗HC和PH方面表现出一定的有效性,具有有利的副作用概况.
- 它作为一个有价值的,耐受性良好的替代品,对于不能耐受indomethacin的患者.
- 黑素为大量患有这些头痛疾病的患者提供了显著的症状改善.
相关概念视频
01:19Management of Insomnia
244
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
244
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
171
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
171
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
61
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
61
01:02The Pineal Gland
1.8K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
1.8K
01:23Sedatives and Hypnotics: Overview
358
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
358
01:27Major Hormones and Their Functions
387
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
387