迷幻疗法:初级护理临床医生的一本书 - - 历史视角和概述
Burton J Tabaac1,2, Kenneth Shinozuka3,4, Alejandro Arenas5
1University of Nevada, Reno School of Medicine, Reno, NV.
American journal of therapeutics
|March 22, 2024
概括
迷幻药物对治疗心理健康状况有希望,但较大的试验表明缓解率与传统抗抑郁药相似. 临床医生应准备将这些新型疗法整合到患者护理中.
科学领域:
- 精神病学和药理学 精神病学和药理学
- 神经科学是一个神经科学.
- 心理健康 治疗方法 治疗方法
背景情况:
- 迷幻药物正在成为潜在的治疗抑郁症,焦虑症和耐治疗神经精神疾病的治疗方法.
- 尽管有进展,但精神疾病仍然是全球公共卫生危机,影响近10亿人.
- 几十年来,附表I状态限制了许多迷幻药的大规模临床试验.
研究的目的:
- 审查目前在迷幻疗法研究的现状.
- 详细介绍涉及各种迷幻化合物的临床试验进展情况.
- 为临床医生提供有关新型药物的信息,并将其纳入精神病治疗.
主要方法:
- 对近期心理治疗药物III期临床试验的审查.
- 对MDMA和psilocybin完成和正在进行的试验的分析.
- 包括对其他迷幻药物的研究,如胺,LSD,DMT,阿雅华斯卡和伊波加因.
主要成果:
- 埃斯凯特胺在2019年被批准用于主要抑郁障碍.
- 在第三阶段试验中,MDMA在PTSD的现有治疗方法上表现出优越性.
- 较大的psilocybin试验显示缓解率为25-29%,与传统抗抑郁药物 (约. 只有30%).
结论:
- 迷幻药物和衍生品对各种精神疾病具有显著的前景.
- 目前的证据表明,psilocybin的缓解率与已知的抗抑郁药类似.
- 临床医生必须熟悉迷幻疗法,以便将其纳入患者护理.
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