迷幻疗法:初级保健医生的一本书 - - 利瑟基酸二甲基胺 (LSD)
Bryce D Beutler1, Kenneth Shinozuka2,3, Burton J Tabaac4,5
1University of Southern California, Keck School of Medicine, Los Angeles, CA.
American journal of therapeutics
|March 22, 2024
概括
Lysergic acid diethylamide (LSD) 显示出作为治疗焦虑,抑郁和酒精使用障碍的有力治疗方法的希望. 需要进一步的大规模研究来确认其治疗潜力并建立临床指南.
科学领域:
- 精神药理学和神经科学研究.
- 研究新型治疗剂的临床试验.
背景情况:
- Lysergic acid diethylamide (LSD) 是一种幻觉性物质,在心理治疗和酒精使用障碍中具有历史性的使用.
- 对精神疾病的担忧导致其在1970年被禁止,使其治疗潜力在很大程度上未被探索.
- 当代研究正在重新评估LSD的疗效和安全性.
研究的目的:
- 审查关于lysergic acid diethylamide (LSD) 的治疗潜力的初步数据.
- 评估LSD在治疗焦虑,抑郁和酒精使用障碍方面的有效性.
- 确定目前LSD研究中的不确定性和局限性的领域.
主要方法:
- 从临床试验和元分析中获得的初步数据的审查.
- 对焦虑,抑郁和酒精使用障碍研究结果的分析.
- 在LSD临床试验中报告的不良事件的评估.
主要成果:
- 初步发现表明,LSD可能对焦虑非常有效,77%的参与者在一次剂量后显示出持久的缓解和50%的一般性焦虑障碍缓解.
- 分析表明,LSD显著改善了酒精使用障碍 (OR=1.96,P < 0.0003).
- 临床试验中的不良事件通常是轻微的和短暂的,尽管患者的选择和剂量需要进一步研究.
结论:
- 初步数据表明,LSD可能是治疗焦虑,抑郁和物质使用障碍的有效治疗方法.
- 一个大规模的当代试验已经完成,突出了进一步进行大样本研究的需要.
- 建立患者选择标准,剂量策略和后续指南对于临床应用至关重要.
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