迷幻疗法:初级保健医生的一本书-N,N-Dimethyltryptamine和阿雅华斯卡
Kenneth Shinozuka1,2, Burton J Tabaac3,4, Alejandro Arenas5
1Centre for Eudaimonia and Human Flourishing, University of Oxford, Oxford, United Kingdom.
American journal of therapeutics
|March 22, 2024
概括
在治疗抑郁症方面,N,N-二甲基三胺 (DMT) 是有前途的. 初步研究表明,它可能比目前的抗抑郁药更有效,但需要更多的研究.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 临床精神病学 临床精神病学
背景情况:
- N,N-二甲基三胺 (DMT) 是一种天然存在的迷幻化合物,在全球各地的各种植物中发现.
- 它是亚亚瓦斯卡中主要的精神活性化合物,传统上作为造品消费.
- 目前正在进行研究,以了解DMT的全部治疗潜力.
研究的目的:
- 调查N,N-二甲基三胺 (DMT) 的治疗效用.
- 探索DMT和阿雅华斯卡在治疗抑郁障碍方面的潜力.
- 评估DMT在临床环境中的安全性和有效性.
主要方法:
- 审查现有临床试验,包括随机对照试验.
- 对涉及静脉注射DMT的IIa期试验初步结果的分析.
- 对阿雅华斯卡及其对治疗耐药抑郁症的影响研究的审查.
主要成果:
- 一项双盲试验表明,在治疗耐药抑郁症患者中,36%的阿雅华斯卡诱导缓解在一周内.
- 一项IIa期试验的早期结果显示,57%的大型抑郁症患者在DMT输注后12周实现了缓解.
- 虽然DMT和阿雅华斯卡通常是安全的,但阿雅华斯卡可能会导致短暂的吐.
结论:
- 初步证据表明,阿雅华斯卡和DMT可能在重度抑郁症和治疗耐药抑郁症中优于现有的抗抑郁药.
- 目前对DMT和阿雅华斯卡的临床研究有限,样本大小小.
- 需要进一步进行严格的研究,以充分确定像DMT这样的迷幻化合物的临床和治疗潜力.
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