迷幻疗法:初级保健医生的一本书-3,4-甲基二氧化甲胺 (MDMA)
Kenneth Shinozuka1,2, Burton J Tabaac3,4, Alejandro Arenas5
1Centre for Eudaimonia and Human Flourishing, University of Oxford, Oxford, United Kingdom.
American journal of therapeutics
|March 22, 2024
概括
3,4-甲基二氧化甲胺 (MDMA) 显示出作为PTSD治疗的显著前景. 临床试验表明,MDMA辅助心理治疗比目前的抗抑郁药更有效,很快就可能合法可用.
科学领域:
- 精神病学和药理学 精神病学和药理学
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 3,4-甲基二氧化甲胺 (MDMA),曾经被称为派对药物,现在被认为具有治疗潜力.
- 关于MDMA风险的现有研究通常基于高剂量动物模型的偏见数据或涉及多种药物使用的人类研究.
研究的目的:
- 评估MDMA辅助心理治疗治疗创伤后应激障碍 (PTSD) 的疗效.
- 探索MDMA辅助心理治疗在其他精神疾病中的潜在应用.
主要方法:
- 由多学科心理学研究协会 (MAPS) 赞助的III期临床试验.
- 根据PTSD的诊断标准和与现有疗法相比的效果大小评估治疗结果.
主要成果:
- 用MDMA辅助的心理治疗显示出很大的效果大小 (d = 0.7-0.91),明显高于传统抗抑郁药.
- 67%-71%的患者在经过18周的MDMA辅助心理治疗后不再符合PTSD标准.
- 对于酒精使用障碍和社会焦虑症也观察到有希望的结果.
结论:
- 在PTSD治疗中,MDMA辅助疗法比目前的抗抑郁药物更优越.
- 需要进一步的研究来比较MDMA辅助治疗与非药物治疗,如认知行为疗法.
- 随着MAPS的FDA提交,MDMA辅助治疗PTSD可能在2024年合法获得.
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