决策网络上的电效应与脉动效应:重塑神经激活格局
Paul W Adkisson1, Cynthia R Steinhardt1,2,3, Gene Y Fridman1,4
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, United States of America.
Journal of neural engineering
|March 22, 2024
概括
电动刺激 (GS) 为神经刺激提供了脉动刺激 (PS) 的有希望的替代方案. 在 silico 中,GS 显示出比 PS 更自然的神经发射模式,特别是经过仔细的参数化.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 生物医学工程 生物医学工程
背景情况:
- 由于安全原因,双相脉动刺激 (PS) 是目前的神经电刺激的标准.
- 尽管PS在实现功能成果方面有效,但它存在局限性.
- 加尔瓦尼刺激 (GS),涉及延长电流输送 (>1s),正在重新出现作为一种替代方案.
研究的目的:
- 调查脉动刺激 (PS) 和电磁刺激 (GS) 之间的差异.
- 在决策皮质网络模型中比较神经对PS和GS的反应.
- 评估GS作为神经刺激中PS的潜在替代品.
主要方法:
- 采用了获胜者占据全部决策的皮质网络模型.
- 模拟神经对脉动刺激 (PS) 和动刺激 (GS) 的反应.
- 分析了时空分布和神经激活的同步.
主要成果:
- 在 silico 结果支持了这样的假设,即 GS 产生了比 PS 更分散的,对网络敏感的反应.
- PS导致一个有限的神经元组的高度同步激活.
- 与假设的偏差发生在具有直接激活或阻断神经元的大型GS幅度.
结论:
- 动刺激 (GS) 可能可以克服脉动刺激 (PS) 的局限性.
- 仔细的GS参数化可以导致更自然的神经发射模式.
- 在需要微妙的神经刺激的应用中,GS显得有前途.
更多相关视频
11:11Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
Published on: September 23, 2017
9.1K
08:24The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
Published on: August 25, 2023
704
相关概念视频
Reason and Intuition
7.7K
The human brain processes information for decision-making using one of two routes: an intuitive system and a rational system (Epstein, 1994; popularized by Kahneman, 2011 as System 1 and System 2, respectively). The intuitive system is quick, impulsive, and operates with minimal effort, relying on emotions or habits to provide cues for what to do next, while the rational system is logical, analytical, deliberate, and methodical. Research in neuropsychology suggests that the...
7.7K
Decision Making: P-value Method
7.3K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
7.3K
Decision Making: Traditional Method
5.8K
The process of hypothesis testing based on the traditional method includes calculating the critical value, testing the value of the test statistic using the sample data, and interpreting these values.
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...
5.8K
Decision Making
1.3K
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
Automatic decision-making is fast, intuitive, and relies on gut feelings...
1.3K
