在人类胎盘中,PFAS会改变胎盘动脉血管结构:一项前性妊娠队列研究
Sadia Firoza Chowdhury1, Nashae Prout2, Zorimar Rivera-Núñez3
1Wynne Center for Family Research, University of Rochester, 601 Elmwood Avenue., Rochester, NY, 14642, USA; Translational Biomedical Sciences Program, University of Rochester, 601 Elmwood Avenue., Rochester, NY, 14642, USA.
Placenta
|March 22, 2024
概括
孕妇在怀孕期间暴露于 perfluoroalkyl 物质 (PFAS) 可能会对胎盘血管发育产生负面影响. 这种胎盘血管变化可以解释PFAS如何影响围产期和儿童健康结果.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 围产期流行病学 围产期流行病学
背景情况:
- perfluoroalkyl物质 (PFAS) 是广泛使用的合成化学物质,与不良健康结果有关,包括围产期风险.
- 胎盘在胎儿发育中起着至关重要的作用,它的结构和功能可能会受到环境暴露的影响.
- 了解PFAS如何影响胎盘发育是阐明其对儿童健康影响的关键.
研究的目的:
- 调查母亲在产前暴露于PFAS和胎盘血管化之间的关联.
- 确定改变的胎盘血管化是否调解了PFAS暴露和出生结果之间的关系.
主要方法:
- 一项前性队列研究,分析了158名终产胎盘中第二个三个月的PFAS水平.
- 使用贝叶斯核机器回归来分析PFAS的混合物.
- 从动脉痕迹评估了胎盘动脉血管结构,与出生结果相关.
主要成果:
- 更高的 perfluorooctanoic 酸 (PFOA) 度与降低的胎盘表面血管 (β = -0.23) 相关.
- 增加的胎盘动脉曲与较低的胎盘重量有关 (β = -0.19).
- 在这些关联中没有观察到基于性别的显著差异.
结论:
- 暴露于PFAS似乎改变了胎盘血管功能的关键指标.
- 这些血管变化可能是PFAS影响围产和儿童健康的机制.
- 这项研究提供了初步证据,将PFAS,胎盘血管性和不良健康结果联系起来.
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