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关于在双连续色谱床中有效纵向扩散的建模
Alessandra Adrover1, Claudia Venditti1, Gert Desmet2
1Dipartimento di Ingegneria Chimica Materiali Ambiente, Sapienza Università di Roma, Italy.
Journal of chromatography. A
|March 22, 2024
概括
新的模型将有效纵向扩散 (Deff) 的理解扩展到双连续色谱包装. 这项研究增强了连续和不连续系统中带宽的模型.
科学领域:
- 染色体学 染色体学 是一种染色学.
- 化学工程是化学工程的重要组成部分.
- 物理化学 物理化学
背景情况:
- 不连续色谱床具有有效的纵向扩散 (Deff) 或B项带宽的模型.
- 双连续包装,就像单立柱一样,在移动和静止区域提供连接的溶液通路.
- 密集的球形颗粒床的行为需要关于连续与双连续处理的澄清.
研究的目的:
- 将现有的Deff模型扩展到双连续包装.
- 开发适用于不连续和双连续系统的有效区域扩散因子 (γm和γs) 的分析模型.
- 在各种双连续包装类型中验证拟议的模型.
主要方法:
- 采用双区域动量分析 (TZMA) 方法来表达Deff.
- 开发了两个有效区域扩散因子 (γm和γs) 的分析模型.
- 研究了各种双连续包装:四面体骨架模型 (TSM),三周期最小表面 (TPMS) 单体和随机包装的球体.
主要成果:
- 拟议的模型准确地预测了Deff对两连续包装的多孔性和区域保留因子 (k′′) 的广泛范围.
- 模型显示TSM,TPMS单体和随机包装的球体的高精度.
- 对单质二氧化,完全多孔和多孔外粒子列的文献数据的验证是成功的.
结论:
- 开发的模型成功地将有效纵向扩散的预测扩展到双连续色谱系统.
- 这些模型为各种双连续包装,包括单立柱,提供了准确的Deff预测.
- 这些发现有助于全面了解包装颗粒床和单体色谱中的溶解物运输.
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