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Updated: Jun 30, 2025

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
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在急性胰腺炎后的各种小鼠菌株中,葡萄糖恒温和小岛损伤的差异

Deren Du1, Xinwu Wang2, Han Zuo3

  • 1Department of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Biochemical and biophysical research communications
|March 22, 2024
PubMed
概括

这项研究比较了后胰腺炎糖尿病 (PPDM) 的小鼠模型. FVB/NJ雄性小鼠表现出显著的岛屿损伤和胰岛素分泌受损,使它们成为PPDM研究的合适模型.

关键词:
葡萄糖的恒常性是葡萄糖的恒常性.岛屿的伤害是小岛的伤害.鼠标模型模型这是一个PPDM.

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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