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在XRCC2基因多态和腹部肥胖之间对子宫内膜癌风险的相互作用

Wenjuan Tian^1,2, Siyu Cao^1,2, Wei Zhang^1,2

¹Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

|March 22, 2024

概括

在XRCC2基因中的rs718282-T等位基因与更高的子宫内膜癌风险有关. 这种风险在与腹部肥胖相结合时会被放大,这表明了显著的基因环境相互作用.

科学领域:

遗传学是一个遗传学.
在瘤学瘤学.
环境健康环境健康

背景情况:

子宫内膜癌 (EC) 风险受遗传和环境因素的影响.
像XRCC2这样的DNA修复基因中的单核酸多态 (SNP) 可能发挥作用.
腹部肥胖 (AO) 是众所周知的各种癌症的风险因素,包括EC.

研究的目的:

研究XRCC2基因中的三个SNP与EC风险之间的关联.
检查与EC风险相关的这些XRCC2SNP和腹部肥胖之间的相互作用.

主要方法:

在研究参与者中对三种XRCC2SNP (rs718282,rs3218536,rs3218384) 的基因定型.
哈迪-韦恩伯格平衡测试使用SNPstats.
一般化多因素缩小维度 (GMDR) 用于选SNP-SNP和基因-AO相互作用.
后勤回归分析用于评估个别SNP和基因环境关联.

主要成果:

rs718282-T等位基因与EC风险增加显著相关 (OR=1.67,95% CI:1.23-2.04).
没有发现rs3218536和rs3218384与EC敏感性有显著的关联.
在GMDR分析中,发现了一种涉及rs718282和AO的显著双位点模型 (测试准确率为60.11%,p<0.001).
与CC基因型的非肥胖个体相比,患有AO和rs718282-CT或TT基因型的个体具有最高的EC风险 (OR=2.83,95%CI:1.67-4.02).

结论:

rs718282-T等位基因是子宫内膜癌的危险因素.
在rs718282基因型和腹部肥胖之间存在显著的相互作用,改变了EC风险.
这些发现强调了在EC病因学中考虑基因环境相互作用的重要性.

关键词:

腹部肥胖症腹部肥胖症进行X射线修复的交叉补充小组.宫内膜癌 (Endometrial Carcinoma) 是一个体内膜癌.互动互动互动互动互动.单个核酸的多形态.

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