基因预测的情绪波动增加了心血管疾病的风险:来自孟德尔随机化分析的证据
Zirui Liu1, Haocheng Wang1, Zhengkai Yang1
1Department of Cardiology, First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Journal of affective disorders
|March 22, 2024
概括
情绪波动显著增加心血管疾病的风险,如CAD,MI,HF和中风. 高血压部分调解了这些因果关系,突出了预防的关键联系.
科学领域:
- 遗传学和心血管流行病学
- 门德尔的随机化研究研究.
- 复杂的特征遗传学复杂的特征遗传学
背景情况:
- 情绪波动与心血管疾病 (CVD) 的风险增加有关.
- 情绪波动和心血管疾病之间的确切因果关系仍然不清楚.
- 调查遗传倾向提供了一个强大的方法来推断因果关系.
研究的目的:
- 确定基因预测的情绪波动与五种主要心血管疾病之间的因果关系.
- 探索潜在的调解途径,特别是高血压的作用.
- 为了利用大规模的全基因组关联研究 (GWAS) 数据进行强大的遗传分析.
主要方法:
- 一个孟德尔随机化 (MR) 分析,利用来自大型GWAS数据集 (n=373,733) 的总结统计数据.
- 采用了各种MR技术,灵敏度分析,多变量MR (MVMR) 和调解分析.
- 使用独立的FinnGen数据集验证了结果.
主要成果:
- 在冠状动脉疾病 (CAD),心肌梗塞 (MI),心力衰竭 (HF) 和中风中发现了情绪波动的显著因果关系.
- 对心房动 (AF) 没有观察到显著的因果作用.
- 高血压被确定为从情绪波动到CAD,MI,HF和中风的因果途径中的显著调解者.
结论:
- 情绪波动对CAD,MI,HF和中风的发展产生显著的因果影响.
- 高血压在这些观察到的因果关系中起着部分调解作用.
- 这些发现强调了考虑情绪和心血管健康的重要性.
相关概念视频
Human Genetics
566
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
566
Bipolar Disorder
67
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
67
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Genetic Lingo
102.7K
Overview
102.7K
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K


