在中国成年人中重金属和金属化物暴露和肝功能 - - 一项全国代表性的横截面研究
Shiyu Wang1, Yuebin Lyu2, Saisai Ji2
1Chinese Center for Disease Control and Prevention, Beijing, China.
Environmental research
|March 22, 2024
概括
在中国成年人中,重金属和金属化物 (HMM) 暴露与肝功能生物标志物的改变有关. 可能会提供肝脏保护,而和会带来风险,强调需要提高公众健康意识.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物标志物 生物标志物
背景情况:
- 重金属和金属化物 (HMM) 是中国普遍存在的环境污染物.
- 在中国人群中,HMMs对肝脏健康的影响尚未得到充分证实.
- 了解这些关联对于公共卫生倡议至关重要.
研究的目的:
- 评估在大量中国成年人中暴露于各种HMM和肝功能生物标志物之间的关联.
- 研究酒精摄入量,性别和年龄等因素对这些关联的影响.
- 为了识别特定的HMMs,构成风险或提供保护肝脏健康.
主要方法:
- 分析了中国国家人类生物监测调查的9445名参与者的数据.
- 在血液和尿液样本中测量11个HMM度.
- 使用血清白蛋白 (ALB),氨酸转移酶 (ALT) 和酸氨转移酶 (AST) 水平评估肝脏健康状况.
- 统计分析以确定HMMs和肝脏生物标志物之间的关系,控制混因素.
主要成果:
- 血中和的升高水平与不良的肝功能标志物 (较低的ALB,较高的AST) 有关.
- 血液中的显示出对肝脏健康的潜在保护作用.
- 关联因饮酒量,性别和年龄而异,表明了复杂的相互作用.
- 尿液HMM混合物和肝功能生物标志物之间没有发现显著的关联.
结论:
- 暴露于HMM,特别是,和,对中国成年人的肝脏健康有复杂的影响.
- 低剂量HMM暴露需要公众健康的关注.
- 可能对肝脏健康有有益影响,值得进一步研究.
- 确定因果关系需要进一步的研究.
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