相关实验视频

Updated: May 13, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

用于肺部感染的双重活性向治疗的化物功能化基托桑基微

Delia Mihaela Rata¹, Anca Niculina Cadinoiu¹, Leonard Ionut Atanase²

¹"Apollonia" University of Iasi, Pacurari Street, No. 11, 700511, Iasi, Romania.

International journal of biological macromolecules

|March 22, 2024

概括

新的装有药物的微囊被开发用于治疗肺部感染. 这些微囊具有特定的功能,向肺细胞和细菌,显示出增强肺部感染治疗的前景.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
制药科学制药科学

背景情况:

肺炎和肺结核等肺部感染,由于微生物耐药性和潜在的并发症,造成了重大治疗挑战.
当前的治疗策略往往在针对性和有效性方面扎,需要创新的方法.

研究的目的:

开发新型含药,功能化的微囊,用于双重活性向和肺部感染的治疗.
使用碳氧化奇托 (CMCS) 和聚乙醇 (PVA) 在双乳液制备微囊的方法.

主要方法:

使用CMCS,PVA和DMT-MM激活器的双乳液技术制备微囊.
使用CGSPGWVRC和的微的表面功能化,用于双重向.
使用FTIR光谱学,尺寸分析,PBS中胀研究,血液溶解试验,肺细胞和巨细胞的细胞毒性评估和内化试验进行表征.

主要成果:

FTIR证实了和胺键的形成,表明微囊的合成成功.
微囊直径在893到965nm之间,PBS在pH7.4下显著膨胀 (1760-2100%) 在pH7.4下.
样本表现出低血解 (<2%),表明非血解性质,并显示对肺细胞和巨细胞的非毒性至轻微细胞毒性影响. 在细胞内水平上证实了内部化.

结论:

质功能化微体显示出有效的双重活性向肺部感染的潜力.
开发的微囊显示出良好的生物相容性和细胞吸收,这表明对先进的肺药物递送系统有希望.

关键词:

关于CGSPGWVRC质的研究碳氧甲基基托桑是一种碳氧甲基基托桑.血红不相容性血红不相容性在体外试验试验印洛西丁可以作为一种.

更多相关视频

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...