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Updated: Jun 30, 2025

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

在急性水出血 (REACT-AVB试验) 中对Early transjugular intrahepatiC porT系统性支架转移进行随机对照试验的研究方案

Dhiraj Tripathi^1,2, David Patch³, Homoyon Mehrzad⁴

¹Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, Birmingham, UK d.tripathi@bham.ac.uk.

BMJ open gastroenterology

|March 22, 2024

概括

这项研究评估了早期的横内肝移植系统支架 (TIPSS) 与肝硬化中急性水出血的标准护理. 它评估了临床和成本效益,以改善患者的生存和结果.

科学领域:

肝病学肝病学是一种肝病学.
胃肠病学胃肠病学
干预性放射学干预性放射学

背景情况:

肝硬化中的急性水出血 (AVB) 携带高死亡风险.
目前关于AVB早期跨内肝内移植系统支架 (TIPSS) 的数据是不确定的.
该REACT-AVB试验调查了AVB管理中的早期TIPSS.

研究的目的:

为了确定早期TIPSS的临床有效性,与AVB在肝硬化中的标准护理相比.
评估早期TIPSS的成本效益.
改善肝硬化和AVB患者的无移植生存率.

主要方法:

一个多中心,随机对照,开放标签优越性试验 (REACT-AVB).
将早期TIPSS (4天内) 与内镜治疗加非选择性β阻塞剂进行比较.
包括患有肝硬化 (查尔德·皮格评分7-13) 和AVB后血液静止的患者.

主要成果:

主要结局:1年无移植生存率.
二次结果:再出血,不良事件,生活质量和成本效益.
样本大小为294名患者在30家英国医院超过4年.

结论:

早期的TIPSS可能为肝硬化中AVB提供更有效的治疗策略.
该试验将提供关于早期TIPSS的临床和经济益处的关键数据.
结果将为目前的AVB治疗指导方针提供信息.

关键词:

脊髓皮质变化脊髓皮质变化脊髓皮质变化胃肠道出血胃肠道出血消化道静脉的发生超高压的门户网站发言人发言人

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