在肺高血压中Sendaway毛细管NT-proBNP
Harrison D Stubbs1,2, John Cannon3, Emily Knightbridge3
1Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK harrison.stubbs@ggc.scot.nhs.uk.
BMJ open respiratory research
|March 22, 2024
概括
桑达韦NT-proBNP测试显示了远程肺高血压监测的潜力. 虽然3天后的毛细血管样本有一些问题,但毛细血管和静脉送体检测在很大程度上保持了准确的患者风险分层.
科学领域:
- 心脏病学 心脏病学
- 生物标志物的分析分析.
- 远程监控患者的监控.
背景情况:
- N-终端亲B型尿素 (NT-proBNP) 是心室室壁应激的一个关键生物标志物.
- NT-proBNP是肺高血压 (PH) 风险分层的组成部分.
- 仙达威采样为远程NT-proBNP测试提供了潜在的可能性.
研究的目的:
- 评估医疗外送NT-proBNP测试与标准静脉NT-proBNP测量之间的一致性.
- 评估延迟处理对发送NT-proBNP结果的影响.
- 为了确定远程NT-proBNP测试在PH管理中的实用性.
主要方法:
- 同时采集静脉和毛细血管样本用于外送NT-proBNP测试.
- 样品在收集后的3天和7天后被邮寄和处理.
- 分析包括Passing-Bablok回归和百分比差异图.
主要成果:
- 第三天的毛细血管样本有13%的不足率,不等同于参考样本.
- 第三天,毛细血管NT-proBNP准确地对93.5%的患者进行了风险分层.
- 第三天,静脉发送结果与参考样本相当,风险分层为90.1%的患者.
- 处理延迟 (7天) 导致不可接受的协议和低估NT-proBNP.
结论:
- 桑达韦NT-proBNP采样可以作为虚拟PH诊所的右心室应变的客观测量.
- 在解释延迟发送NT-proBNP样本的结果时,建议谨慎.
关键词:
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