在多发性硬化症患者的脊髓中对IVIM的评估
Brian Johnson1, Christine Heales2
1Brian Johnson, PhD, R.T.(MR)(N), CNMT, works for Philips in Cleveland, Ohio, and the Department of Radiology at the University of Texas Southwestern Medical Center in Dallas.
Radiologic technology
|March 22, 2024
概括
内素不连贯运动 (IVIM) 成像没有显著区分多发性硬化症 (MS) 患者与健康个体的脊髓微循环. 然而,IVIM对评估MS中脊髓变化有希望.
科学领域:
- 神经成像是一种神经成像.
- 放射学 放射学是一门学科.
- 医学物理 医学物理
背景情况:
- 多发性硬化症 (MS) 是一种影响中枢神经系统的脱髓化疾病.
- 脊髓干扰在MS中很常见,并导致残疾.
- 了解脊髓中的微循环变化对于MS治疗至关重要.
研究的目的:
- 评估Intravoxel不连贯运动 (IVIM) 磁共振成像 (MR) 在检测MS患者脊髓微循环变化的有用性.
- 为了比较患有多发性硬化症和健康对照人群之间的IVIM衍生指标.
主要方法:
- 15名健康人群和15名多发性硬化症患者接受了3T IVIM MR成像.
- 使用2D轴度梯度召回回声和扩散加权成像 (DWI) 序列.
- 使用未配对的t测试计算和比较IVIM指标 ( perfusion 分数,伪扩散,扩散系数).
主要成果:
- 在MS患者和健康个体之间没有观察到IVIM指标的统计学上显著差异.
- 感兴趣的白质区域显示了 perfusion 分数和伪扩散的最低P值 (分别P=0.082和P=0.055).
- 感兴趣的灰质区域表现出更高的P值,表明差异较小.
结论:
- 与对照组相比,目前的IVIM参数没有显著区分MS患者的脊髓微循环.
- 这项研究与MS中的基于大脑的IVIM发现一致,表明MS患者的灰质 perfusion 可能减少.
- IVIM成像对未来评估MS中脊髓微血管和扩散特征充满希望,可能有助于疾病进展和治疗监测.
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