通过在纳米结构脂质载体中通过固体脂质和脂质的内部结构调节提高醇的酸稳定性
Simin Feng1, Jialu Sheng2, Jiahao Yu1
1Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, People's Republic of China; Key Laboratory of Food Macromolecular Resources Processing Technology Research (Zhejiang University of Technology), China National Light Industry, People's Republic of China.
Food research international (Ottawa, Ont.)
|March 22, 2024
概括
这项研究在使用化大豆脂 (HPC) 的纳米结构脂质载体 (NLC) 中增强了的稳定性. 在HPC中改进了NLC.
科学领域:
- 制药纳米技术 制药纳米技术
- 药物输送系统 药物输送系统
- 基于脂质的配方 基于脂质的配方
背景情况:
- 是一种有价值的化合物,在酸性环境中稳定性不佳.
- 纳米结构脂质载体 (NLCs) 为疏水化合物提供了一个有前途的输送系统.
- 调节NLC内部结构是提高货物的稳定性的关键.
研究的目的:
- 研究脂和固体脂质对NLCs内部结构的影响.
- 为了实现稳定的封装和提高的酸性稳定性.
- 探索脂点和结在NLC稳定性中的作用.
主要方法:
- 使用莱西PC和化大豆脂 (HPC) 制备NLCs.
- 包括粒子大小,多分散率指数 (PDI) 和泽塔潜力在内的NLCs的表征.
- 在酸性条件下 (2 mM 和 20 mM HCl) 评估醇保留率.
- 对再结晶指数 (RI) 的分析,以评估脂质矩阵结晶度.
主要成果:
- 基于HPC的NLC保持了最佳粒子大小 (155.9-186.9nm) 和PDI (0.182-0.321).
- 在具有HPC NLCs的酸性环境中实现了高醇保留率 (91.33-98.49%).
- 增加的固体脂质键与更高的再结晶指数相关,表明脂质矩阵结晶性发生变化.
- 高点HPC有效抑制了β-化并稳定了.
结论:
- 脂点和结数显著影响NLC结晶性和稳定性.
- 化脂 (HPC) 的高点是优越的稳定封装.
- 这项研究提供了一种新的方法来增强醇的酸性稳定性,扩大其在酸性饮料中的应用.
相关概念视频
Assembly of the Lipid Bilayer in the ER
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
Micelles
Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Biosynthesis of Lipids
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis pathway, which...


