相关实验视频
Updated: May 1, 2026

08:37
Measuring Enzymatic Stability by Isothermal Titration Calorimetry
Published on: March 26, 2019
13.1K
乳酸铁素-多糖化合物的热稳定性和体外生物命运
Hanyun Jiang1, Tingting Zhang1, Yujie Pan1
1Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.
Food research international (Ottawa, Ont.)
|March 22, 2024
概括
卡拉基南和桑坦改善了乳酸的热稳定性和消化能力. 蛋白质多糖化合物复合物增强LF的胃肠道吸收和婴儿配方奶粉的应用.
科学领域:
- 食品科学 食品科学 食品科学
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
背景情况:
- 乳酸 (LF) 是一种对热量敏感的重要糖蛋白,影响其功能.
- 热处理导致变质和聚合,降低LF的有效性.
- 开发提高LF稳定性的方法对于食品应用至关重要.
研究的目的:
- 使用蛋白质多糖化合物复合物来提高乳酸铁素 (LF) 的热稳定性.
- 评估LF复合物的体外婴儿消化和吸收特性.
- 探索LF在婴儿食品配方中的复杂应用.
主要方法:
- 使用 LF. carrageenan (CG),Xanthan gum (XG) 和 locust bean gum (LBG) 形成蛋白质多糖化合物.
- 在复合体中进行热处理后评估LF结构变化 (α-螺旋).
- 在体外模拟婴儿消化和Caco-2细胞吸收研究.
主要成果:
- 在加热过程中,LF-CG和LF-XG复合体显著抑制了LF的α螺旋结构损失.
- 在模拟婴儿胃消化和减缓肠道降解过程中,LF-CG和LF-LBG保护了LF.
- 在100μg/mL时,LF-XG增强了Caco-2细胞对消化产品的吸收.
结论:
- 蛋白质多糖复合增强了LF的热处理稳定性.
- 卡拉基南,桑坦和豆改善了LF的胃肠道稳定性和吸收.
- 这些发现支持婴儿食品的发展,提高LF稳定性和营养吸收.
相关概念视频
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
733
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
733
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
332
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
332
Microbes in Food Production
403
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
403
Production of Organic Acids
105
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
105

