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在活体捐赠者肝移植之后的恶性病变
Takashi Kobayashi1, Kohei Miura2, Hirosuke Ishikawa2
1Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Transplantation proceedings
|March 22, 2024
概括
肝移植 (LT) 后的新发恶性病 (DNM) 显著降低了存活率. 在LT之前的吸烟史是一个危险因素,而R0切除改善了这些癌症的结果.
科学领域:
- 肝病学和移植外科手术
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 新生恶性瘤 (DNM) 是长期肝移植 (LT) 接受者死亡的重要原因.
- 活体捐献者LT (LDLT) 是等待已故捐献者器官的患者的替代方案,但DNM风险需要调查.
研究的目的:
- 报告活体捐赠者肝移植 (LDLT) 后成年接受者的新发性恶性瘤 (DNM) 的发生率,特征和结果.
- 确定LDLT后DNM的风险因素和预后指标.
主要方法:
- 从1999年到2022年,对70名成年LDLT接受者进行了回顾性分析,他们生存时间超过1年.
- 对新发恶性瘤的发展,癌症类型,治疗和生存的随访.
主要成果:
- 在7名接受者 (肺癌,移植后淋巴增殖性疾病,皮肤癌) 中发生了8种DNM.
- 在LT前的吸烟史是一个显著的风险因素 (P=.004).
- 20年后,累计DNM发病率达到18.4%;DNM患者的存活率更差 (P=.049).
结论:
- 在LDLT之后的De novo恶性瘤 (DNM) 与生存率降低有关.
- 移植前的吸烟是DNM的一个危险因素.
- R0切除对于改善预后至关重要;为早期检测,建议定期进行癌症查.
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