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较高剂量的与创伤患者的生存相关
Dillon J Wade1, Collin Pilkington1, J Curran Henson1
1Division of Trauma and Acute Care Surgery, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
The Journal of surgical research
|March 22, 2024
概括
在创伤患者的大规模输血期间增加的给药与更好的生存率和减少血液制品的使用有关. 这一发现凸显了在治疗严重受伤患者中的重要性.
科学领域:
- 创伤重症监护中心的重症监护中心.
- 复苏药物是一种复苏药物.
- 临床生物化学 临床生物化学
背景情况:
- 对于凝血,心脏输出和血管抵抗至关重要.
- 低血症影响了接受大量输血的创伤患者的85-94%.
- 创伤复苏需要谨慎的电解质管理.
研究的目的:
- 为了研究在大量输血和创伤患者的生存期间增加静脉的管理之间的联系.
- 为了确定更高的剂量是否与大规模输血协议中改善的结果相关.
- 评估补充对血液产品需求的影响.
主要方法:
- 追溯分析77名接受大量输血的创伤患者.
- 计算元素剂量的与血液产品比率 (CBR).
- 多变量逻辑回归控制伤害严重性得分,凝血病,年龄和性别.
主要成果:
- 较高的CBR与30天生存率的改善有关 (P<0.05).
- 增加的CBR与每位患者输血的血液制品总量显著减少相关 (P <0.05).
- 每单位超过50毫克元素的CBR是生存的预测指标.
结论:
- 每个血液制品单位的较高剂量与创伤患者的30天生存率的改善有关.
- 增加的使用可能会导致整体血液产品输血减少.
- 管理是创伤大规模输血协议的关键组成部分.
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