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微粒对输血储存的红细胞缩物的不良影响
Jie Yang1, Yiming Yang1, Li Gao1
1Shanghai Institute of Blood Transfusion, Shanghai Blood Center, Shanghai, China.
Hematology, transfusion and cell therapy
|March 22, 2024
概括
储存红细胞 (RBC) 度中的微粒物促进血液凝结并激活肺内皮细胞,可能导致输血相关的急性肺损伤 (TRALI). 这项研究研究了它们的前凝和前炎作用.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 与输血相关的急性肺损伤 (TRALI) 具有凝血病和炎症的特征.
- 储存红血细胞 (RBC) 度中微粒在TRALI病变发生过程中的作用尚未完全理解.
研究的目的:
- 为了确定存储的红细胞中的微粒能否促进血栓生成.
- 研究这些微粒激活和破坏人类肺微血管内皮细胞 (HMVECs) 的能力.
主要方法:
- 使用流细胞计和纳米粒子跟踪分析量化和测量微粒的尺寸.
- 对血栓生成 (校准自动血栓图) 和凝血 (aPTT) 的检测.
- 评估HMVEC激活 (ICAM-1表达,细胞因子释放) 和损伤 (预备的多态核中性粒细胞).
主要成果:
- 红细胞超标中的微粒 (100-300 nm) 促进了剂量依赖的血栓生成,并缩短了aPTT.
- 耗尽微粒物减少了前凝剂的活性.
- 微粒物增加了来自HMVECs的ICAM-1表达,IL-6和IL-8释放.
- 微粒通过PMN激活诱导HMVEC损伤,通过抑制PMN呼吸口爆发可以预防.
结论:
- 储存的红细胞中的微粒具有前凝和前炎性质.
- 这些微粒激活和破坏HMVECs,这表明它们在TRALI发育中的作用.
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