在健康的狗中,胃肠道释放延迟释放和凝囊的释放部位
Charles B Stone1,2, Adam J Rudinsky1,2, Rebecca J Urion1
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Journal of veterinary pharmacology and therapeutics
|March 23, 2024
概括
延迟释放囊没有将其内容输送到狗的小肠,而是在胃中释放. 这一发现影响了狗研究中的药物输送和便微生物群移植结果.
科学领域:
- 兽医药理学 兽医药理学
- 胃肠道生理学 胃肠道生理学
- 药物输送系统 药物输送系统
背景情况:
- 凝囊释放胃中的内容.
- 延迟释放 (DR) 囊是用于肠道药物输送的.
- 了解狗的胃肠道过渡对于有效的药物配方至关重要.
研究的目的:
- 为了评估狗的DR囊的胃肠道释放部位.
- 在狗模型中,将DR囊释放与标准的凝囊进行比较.
- 评估生理条件对狗的DR囊释放的影响.
主要方法:
- 给六只健康的成年狗注入了含有浸聚乙烯球体 (BIPSTM) 的凝和DR囊.
- 使用腹部放射图来追踪BIPSTM在摄入后的不同时间点释放的情况.
- 研究包括禁食条件,增加食大小,双重封装和改变囊大小.
主要成果:
- 凝和DR囊在所有评估阶段都在胃中释放了BIPSTM.
- 在禁食的狗中,DR囊的释放时间显著延长 (中位数为60分钟),与凝囊 (15分钟) 相比 (p=0.03).
- 试点研究表明,即使改变了食或囊参数,DR囊的胃释放时间也会延长.
结论:
- 在狗中,DR囊不能确保肠道输送,主要在胃中释放内容.
- 这与人类的DR囊行为形成鲜明对比,并对胃敏感疗法产生影响.
- 临床医生和研究人员在假设在犬类应用中对DR囊进行肠道输送时应谨慎行事.
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