相关实验视频
Updated: Jun 30, 2025

03:46
Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
Published on: October 11, 2018
10.1K
在睡眠不足的条件下,神经特洛芬,情绪和身体活动之间的相互作用
Marcin Sochal1, Marta Ditmer2, Agata Binienda3
1Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, Poland. sochalmar@gmail.com.
Translational psychiatry
|March 23, 2024
概括
睡眠不足会影响神经营养素水平,其中质细胞系衍生的神经营养素 (GDNF) 和神经营养素-3 (NT3) 可能会影响情绪反应. 睡眠不足期间的体力活动可能会影响神经营蛋白mRNA的表达.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 精神病学是一个精神病学.
背景情况:
- 大脑衍生神经营养因子 (BDNF) 与睡眠不足 (DS) 后的情绪变化有关,但其他神经营养素的作用不太清楚.
- 神经营养素对神经元的生存,生长和功能至关重要,它们的调节失调与情绪障碍有关.
研究的目的:
- 研究DS对BDNF,GDNF,NT3和NT4的mRNA和蛋白质水平的影响.
- 为了探索这些神经特洛芬和情绪变化之间的关系后DS.
- 为了检查体力活动 (PA) 在DS期间对神经营养素表达的影响.
主要方法:
- 81名参与者接受了多睡眠扫描 (PSG) 和DS,采集了血液样本,情绪评估和动图数据.
- 测量了白细胞和血清蛋白度中的神经缩mRNA表达.
- 参与者根据DS后情绪变化被分为响应者和非响应者.
主要成果:
- DS降低了BDNF mRNA,但没有改变血清BDNF蛋白.
- 在非响应者中,GDNF蛋白降低,而在响应者中,GDNF mRNA降低.
- NT3蛋白普遍增加,NT3 mRNA在响应者中减少,NT4蛋白增加,而其mRNA保持不变.
- 身体活动与DS后BDNF,GDNF和NT3的mRNA表达负相关.
结论:
- 在DS之后,GDNF和NT3可能在情绪调节中发挥重要作用.
- 在DS期间的体力活动可能会损害白细胞中神经质mRNA的表达.
- 需要进一步的研究来澄清BDNF和NT4的作用,考虑到它们的潜在冗余性.
相关概念视频
Insufficient Sleep and Sleep Deprivation
141
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
141
Understanding Sleep
228
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
228
Narcolepsy
102
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
102
Depression: Overview
242
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
242
Sleep-Wake Cycles
1.3K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.3K
Nightmares and Night Terrors
87
Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
Nightmares...
87

