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Updated: Jun 15, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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在上皮卵巢癌中识别潜在的可采取行动的遗传变异:一个回顾性队列研究

Charlotte Fieuws1,2,3, Joni Van der Meulen1,2,3, Kristiaan Proesmans4

  • 1Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.

NPJ precision oncology
|March 23, 2024
PubMed
概括

这项研究分析了351名卵巢癌患者的遗传变异,在很小比例的患者中发现了BRCA1/2变异,但有许多其他可操作的突变. 这些发现可能会指导个性化卵巢癌治疗.

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...