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基于活检的最小侵入性诊断以支持精确的癌症医学

Bo Franzén^1,2, Gert Auer¹, Rolf Lewensohn^1,3

¹Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Molecular oncology

|March 23, 2024

概括

细针吸收活检 (FNA) 分子细胞学为实体瘤诊断提供了核心针活检的患者友好的替代方案. 这种微侵袭性技术有助于适应性治疗决策和瘤微环境的表征.

科学领域:

在瘤学瘤学.
病理学病理学病理学
分子诊断学分子诊断

背景情况:

针对固体瘤的精密癌症医学 (PCM) 需要最少的侵入性诊断技术.
目前的诊断方法,如核心针活检 (CNB) 可能是创伤性的,并导致并发症.

研究的目的:

描述基于细针吸收活检 (FNA) 的分子细胞学的发展和倡导的实施.
将FNA分子细胞学作为瘤采样中CNB的患者友好和有效替代品.

主要方法:

开发基于FNA的分子细胞学技术.
超敏感分子方法与图像引导FNA的整合.
使用FNA样本对瘤微环境的表征.

主要成果:

FNA分子细胞学显示,在各种瘤类型中,有很大的潜力可以替代CNB.
使用分子方法的图像引导FNA使瘤微环境的表征成为可能.
FNA的可重复性有助于定期采样以进行适应性治疗.

结论:

基于分子FNA的采样是一种患者友好的诊断方法,有可能取代CNB.
这种技术支持明智的治疗决策,缩短医疗服务的交付时间,并提供经济效益.
建议增加分子FNA的实施,以改善癌症治疗和诊断.

关键词:

生物标志物生物标志物精细的针吸入器吸入器免疫信号传递是免疫信号传递.最少侵入性诊断的诊断方法固体瘤是一种固体瘤.瘤微环境是一个微环境.

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